Blog

Protein Folding and Design

AI’s role in impacting protein folding and design

If you are wondering if AI is just a fad and doesnโ€™t have a impactful real world use case then think again.

๐๐จ๐›๐ž๐ฅ ๐๐ซ๐ข๐ณ๐ž in Chemistry was just awarded ๐†๐จ๐จ๐ ๐ฅ๐ž ๐ƒ๐ž๐ž๐ฉ๐Œ๐ข๐ง๐โ€™๐ฌ ๐‚๐ก๐ข๐ž๐Ÿ ๐„๐ฑ๐ž๐œ๐ฎ๐ญ๐ข๐ฏ๐ž ๐š๐ง๐ ๐‚๐จ-๐Ÿ๐จ๐ฎ๐ง๐๐ž๐ซ ๐’๐ข๐ซ ๐ƒ๐ž๐ฆ๐ข๐ฌ ๐‡๐š๐ฌ๐ฌ๐š๐›๐ข๐ฌ, ๐ƒ๐š๐ฏ๐ข๐ ๐๐š๐ค๐ž๐ซ and ๐‰๐จ๐ก๐ง ๐Œ. ๐‰๐ฎ๐ฆ๐ฉ๐ž๐ซ for predicting protein structure and computational protein design.

How does that help and why should I be elated, you might wonder.

I did the same.

Hereโ€™s the problem they solved and why itโ€™s a big deal.

Imagine you have a long, tangled string of yarn. It’s all messy and twisted up. Now, if you could shake it out and carefully fold it into a specific shape, it would look very different and could even become something useful, like a toy or a decoration.

That’s kind of like what happens with proteins. They’re made up of long chains of tiny building blocks called amino acids. Just like the yarn, these chains can get all tangled up. But when they fold into a specific shape, they become a protein that can do a particular job in your body.

For example, some proteins help build and repair cells, while others fight off germs. The shape of a protein is really important for it to work correctly. If a protein folds the wrong way, it might not be able to do its job properly.

So, protein folding is like a puzzle. The amino acids are the pieces, and the shape of the protein is the solution to the puzzle. When the puzzle is solved, the protein can do its important job in your body!

Scientists knew the order of the amino acids in a protein, but they couldn’t figure out how the protein folded into its shape. This shape is really important because it determines what the protein does in our bodies.

๐€๐ฅ๐ฉ๐ก๐š๐…๐จ๐ฅ๐, a super-smart machine learning application aka puzzle solver can look at the order of amino acids in a protein and predict how it will fold. This is a huge deal because it helps scientists understand how proteins work and how they might be involved in diseases.

How does this help us?

If we understand how a protein involved in a disease is folded, we might be able to design a medicine that stops it from folding the wrong way. This could help people get better from diseases.

This is a problem that has puzzled researchers and scientists for decades on end and Artificial Intelligence seems to have come up with a solution.

I came to know about Demis Hassabis from the book I read called ๐†๐ž๐ง๐ข๐ฎ๐ฌ ๐Œ๐š๐ค๐ž๐ซ๐ฌ and the documentary ๐€๐ฅ๐ฉ๐ก๐š๐†๐จ (Available free on YouTube). Having done both before the launch of ChatGPT, this recognition to Demis and team makes it special for AI/ML enthusiast like me.

Congratulations to Demis Hassabis and the team. Cheers๐Ÿฅ‚

p.s. Drop your email in the followit box to receive my latest blog. We can also stay connected on various social media platforms, just click the links to follow.

 

Leave a Comment

Your email address will not be published. Required fields are marked *